苏黎世联邦理工大学
Doctoral Position on viscoelastic hydrogels for 3D mechanobiology and tissue repair
ETH Zurich | Macromolecular Engineering Laboratory
截止时间: 招满即止
The Macromolecular Engineering Laboratory (Prof. Mark W. Tibbitt) within the Department of Mechanical and Process Engineering (D-MAVT) at ETH Zurich in Zurich, Switzerland engineers and applies advanced polymeric materials for a range of biomedical and industrial uses. The recent focus of the group (www.macro.ethz.ch/) includes the development of: (i) rational design of dynamic polymer networks; (ii) (bio)material processing; (iii) organ perfusion and regeneration; (iv) tools to study mechanobiology and cell–matrix interactions; and (v) engineered drug delivery systems. The lab is composed of a highly interdisciplinary and international team of motivated researchers. To expand on our ability to engineer viscoelastic biomaterials and deploy them as tailorable 3D cell culture platforms for mechanobiology and tissue repair, we are recruiting a full-time (100%) doctoral candidate, with an intended starting date on or after 01. October 2026.
Project background
Viscoelasticity—the ability to relax stress over time—is a defining mechanical feature of most native soft tissues and is increasingly recognized as a critical regulator of cell behavior including proliferation, differentiation, and migration. Dynamic covalent hydrogels (DCHs) are an emerging class of polymer networks that uniquely combine the tunability of reversible covalent bonds with the robustness of permanent networks, enabling independent control over stiffness, relaxation timescale, and injectability. This project aims to harness this tunability to develop a comprehensive library of DCHs as designer extracellular matrix (ECM) mimics, and to apply them to uncover the mechanistic role of matrix viscoelasticity in biological contexts, for example articular cartilage maturation and cancer cell migration.
Job description
In the first part of the project, the doctoral student will synthesize PEG- and hyaluronic acid-based DCHs cross-linked via dynamic covalent chemistries (boronate ester, hydrazone, imine, and disulfide bonds), spanning a broad range of moduli (0.1–100 kPa) and relaxation times (10–1000 s) to mimic the mechanical properties of native and cancer-associated dermal and cartilaginous tissues. The student will fabricate and characterize these materials using rheology and nano-indentation, guided by molecular design insights from the broader project team. In the second part, the student will apply these tailorable DCH scaffolds to address key mechanobiology questions. These studies will provide mechanistic insight into how matrix viscoelasticity drives key tissue-level biological processes.
The doctoral student will work in close collaboration with and be supported by an interdisciplinary team of doctoral students and postdocs working on related topics, including Dr. Céline Labouesse, a Senior Scientist in the lab, and Dr. Philipp Fisch, both experts in cell mechanobiology. In addition to research, the PhD candidate is expected to contribute to lab duties and teaching, including student supervision, lecture support, and practical courses in the lab.
Profile
We are seeking a curious, motivated, and self-driven individual, who is comfortable working on highly interdisciplinary projects at the interface of polymer chemistry, bioengineering, and cell biology. Academic excellence, a professional work attitude, and a proactive and self-driven work ethic are expected. Moreover, the candidate must be able to fluently communicate in English (oral and written) and be willing to work in a highly interactive, international team. Applicants must hold a MSc degree in bioengineering, biomedical engineering, mechanical engineering, molecular health sciences, materials science, chemistry, or related fields. A working knowledge of polymer synthesis and hydrogel fabrication is required. Practical experience in one or more of the following would be advantageous: 3D cell culture and standard biological assays (cell viability, immunostaining, gene/protein expression); mechanical characterization of soft materials (rheology, compression testing); or live-cell imaging and image analysis. The doctoral position is intended for 4 years, at 100% employment, and will be supervised by Prof. Dr. Mark Tibbitt, with day-to-day support from Dr. Céline Labouesse and collaboration with Dr. Philipp Fisch. The position is funded by the Swiss National Science Foundation and is conditional upon admission to the Doctoral Program at ETH Zurich.
Curious? So are we.
We look forward to receiving your application, as a single PDF, including: 1) a cover letter of motivation that describes your scientific interest in this position and main scientific achievements to date (max. 2 pages), 2) CV, 3) diplomas and course transcripts, and 4) the contact details of three or more references. Please submit your application on-line. Applications via email or post will not be considered. For questions about the position, please contact Prof. Tibbitt (mtibbitt AT ethz DOT ch) (note that applications cannot be accepted by email).
慕尼黑工业大学
Doctoral Candidate f/m/d in Plant Cell Biology
TUMt | School of Life Sciences,
截止时间：招满即止
The 机构 Network Bavaria funded graduate college “The Proteomes that Feed the World” at the School of Life Sciences, Technical University of Munich invites applications for: Doctoral Candidate f/m/d in Plant Cell Biology
The graduate college “The Proteome that Feed the World”:
Plants are the nutritional basis of life on earth and for sustaining an increasing human population and counteracting climate change. However, little is known about the crop proteomes – the entirety of proteins that execute and control nearly every aspect of life. Therefore, TUM pursuits for the second time the visionary doctoral program with high socio-economic relevance on the topic of “The Proteomes that Feed the World” with the aims to train and develop future leaders in science who excel in research, management and communication.The program offers professional training and project management structure in which doctoral candidates (DCs) master challenging roles, take on substantial responsibility and acquire important transferable skills.DCs are actively engaged in interdisciplinary cohort of scientists with leading expertise in plant science, cell biology, proteomics and bioinformatics.Added value comes from a large international network of excellent academic and industry partners as well as a vibrant local scientific community.Capitalizing on the proteome atlas of the 100 most important crop plants for human nutrition, the project takes a cell biological perspective to investigate the molecular bases of plant-microbe interactions.
Requirements:
- Candidates must hold an internationally recognized MSc degree in a life science discipline or in (bio-)informatics.
- Candidates must have a good command of the English language and very good interpersonal and intercultural skills. We are looking for self-motivated and broadly interested individuals with a strong sense of responsibility.
Our offer:The position (E13 TV-L, 65%) is offered for four years available from October 1st 2026 onward. You will join an interdisciplinary team of life scientists and bioinformaticians who use the latest cell biology and proteomic approaches to better understand plant biology. The TUM is one of the best academic institutions in Germany, a well worked out international program, offers a stimulating work environment and excellent future perspectives.Application process:Applicants should submit a single PDF containing a motivational statement, a curriculum vitae, and the email addresses of at least two referees to julien.gronnier@tum.de.
The position is suitable for disabled persons. Disabled applicants will be given preference in case of generally equivalent suitability, aptitude and professional performance.
