新加坡国立大学招收博士后两名
想在科研的同时感受新加坡的阳光和东南亚的美食？想在世界顶尖医学院与国际团队一起搞事情？那就快来加入新加坡国立大学杨永玲医学院 GRIT Lab（Genome Re InnovaTion Lab） 吧！
实验室主页👉 https://grit-lab.org
实验室由韩国欧巴级PI 李正俊博士（Dr. Jungjoon Lee） 带队，专注于下一代基因编辑技术开发与安全性评估。李博士在团队中非常关注中国学者，一直以来对中国学生和博士后都特别支持和友好。这次招聘更是明确希望招收两名中国博士后，一起把基因编辑的科研成果推向新高度。
这次我们要找的是两位勇敢无畏的博士后小伙伴：
岗位 1：基因编辑 · 定向进化
主要玩转：噬菌体定向进化、蛋白工程、突变库构建、NGS高通量分析，还有在哺乳动物/原代细胞里的功能验证。
你将会做的事：
- 用噬菌体、E.coli 或人类细胞做定向进化，把基因编辑蛋白“练成更强王者”。
- 搭建突变体库、筛选编辑效果，并用NGS读出结果。
- 在哺乳动物和原代细胞里测功能，不止停留在试管里。
- 指导学弟学妹，和PI一起头脑风暴。
我们希望你有：
- 生物技术、生物化学、生命科学等相关专业博士学位。
- 扎实的分子克隆、文库构建经验。
- 对噬菌体系统不陌生（或者有超强学习热情）。
- 有NGS和基因编辑经验更佳。
- 国际期刊发文记录加分。
岗位2：基因编辑脱靶全景剖析
主要研究：不同染色质/细胞环境下的全基因组编辑数据，结合AI模型预测编辑安全性。
你将会做的事：
- 在永生化细胞、原代细胞、3D类器官里做基因编辑实验。
- 开发测序技术，精准捕捉DNA切割和编辑事件。
- 同时操作 Cas9、碱基编辑器、引物编辑器。
- 与计算团队合作，把实验数据融进AI模型，提升安全预测力。
我们希望你有：
- 分子生物学、生物化学或生物技术等相关专业博士学位。
- 丰富的基因编辑和哺乳动物细胞培养经验。
- 熟练掌握分子克隆、核酸提取、PCR/qPCR、NGS工作流程。
- 有功能基因组学或高通量筛选经验优先。
- 发表过不错的科研论文。
申请方式
请用英文准备以下材料，发邮件到 Dr. Jungjoon Lee (jjk.lee@nus.edu.sg)：
- 详细简历（含教育/科研经历与论文列表）
- 三位推荐人联系方式
- 目前/期望薪资与可到岗时间
- 申请岗位（A、B 或两者）
仅有入围者会收到面试通知。
待遇与合约
薪资按照 NUS 标准（税后约人民币38万元起），再根据你的学历和经验匹配。
岗位由新加坡教育部Tier 2项目支持，研究经费稳定。
为什么选择我们？
这里有：
- 国际一流科研平台 & 新加坡宜居环境。
- 热情靠谱的韩国欧巴PI。
- 团队氛围不止科研，还有咖啡、美食和欢乐吐槽。
来吧！如果你想让基因编辑更精准、更安全，也想让你的科研之路更精彩，就赶快加入GRIT Lab！
Research Fellow (Postdoctoral) Positions — Genome Editing & Off‑Target Profiling
Lab:Genome Re‑InnovaTion (GRIT) Lab — Synthetic Biology Translational Research Programme (TRP), Yong Loo Lin School of Medicine, National University of Singapore (NUS)
Lab site:https://grit-lab.org
Location: Singapore (NUS Medicine)**Informal enquiries: Dr. Jungjoon Lee — jjk.lee@nus.edu.sg
We are recruiting outstanding postdoctoral Research Fellows across two complementary directions in cutting‑edge genome editing. Candidates may indicate interest in one or both roles.
Position A —
Genome Editing (Directed Evolution)
Focus:Phage‑based directed evolution of genome editing proteins; protein engineering; mutant library construction; NGS‑based readouts; validation in mammalian and primary cells.
Key Responsibilities
- Design and perform phage, E.coli or human cell based directed evolution to engineer novel genome editing proteins with improved properties.
- Rationally identify protein engineering sites and build diverse mutant libraries.
- Execute functional assays in mammalian and primary cells to quantify editing efficiency and performance.
- Analyze outcomes using next‑generation sequencing (NGS) and complementary molecular assays.
- Mentor research assistants, graduate and undergraduate students; collaborate closely with the PI and team on planning and troubleshooting.
- Perform other duties as delegated by the PI and group leads.
Qualifications
- PhD in Biotechnology, Biological Sciences, Biochemistry or related field.
- Hands‑on experience in molecular cloning, library construction, and microbial genetics.
- Familiarity with (or strong motivation to learn) phage systems for directed protein evolution.
- Strong critical thinking, independence, and teamwork; NGS‑based genome editing experience is a plus.
- Track record of publications in international, peer‑reviewed journals.
Appointment & Salary
Initial 1‑year contract, renewable based on performance and funding; salary commensurate with qualifications and experience (NUS standards).
Position B —
CRISPR Genome‑wide Off‑Target Profiling
Focus:Generate and analyze genome‑wide editing datasets across diverse chromatin/cellular contexts; integrate with AI models to improve safety prediction; work across Cas9, base editors, and prime editors.
Key Responsibilities
- Design and run genome editing experiments in immortalized lines, primary cells, and 3D organoid cultures.
- Develop/optimize sequencing‑based assays to capture DNA cleavage/editing events at high resolution; manage QC, library prep, and sample tracking for large‑scale workflows.
- Coordinate multi‑tool experiments (Cas9, base editors, prime editors).
- Supervise and train junior team members.
- Collaborate closely with computational colleagues to integrate experimental data into predictive AI models; contribute to manuscripts, presentations, and reports.
Qualifications
- PhD in Molecular Biology, Biochemistry, Biotechnology or related life sciences.
- Extensive hands‑on experience with genome editing and mammalian cell culture.
- Strong skills in molecular cloning, nucleic acid extraction, PCR/qPCR, and NGS workflows.
- Experience in functional genomics or high‑throughput screening is advantageous; familiarity with primary cells/3D cultures is a plus.
- Ability to troubleshoot independently, manage multiple projects, and thrive in a collaborative environment; strong publication record.
Funding & Salary
Position supported by a Ministry of Education (MOE) Tier‑2 grant; salary commensurate with qualifications and experience (NUS standards).
How to Apply (both positions)
Please submit the following (in English preferred):
- Detailed CV — personal particulars; education and employment history; full list of publications/oral presentations.
- Contact information for three referees.
- Current/expected salary and earliest start date.
- (Optional) Indicate the position(s) you are applying for (A, B, or both) and any job reference number.
Only shortlisted candidates will be contacted for interview.
Submission / Enquiries:
Email your application and any questions to Dr. Jungjoon Lee (jjk.lee@nus.edu.sg).
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